Basic Information
VIS ID
TVIS44020879
Fusion event
HTLV-1-EIF2S1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
67834775/67368058 (Hg38)
End
67834775/67368058 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
EIF2S1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-375 ; hsa-mir-192-5p ; hsa-mir-222-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-376c-5p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-20b-5p ; hsa-mir-376b-5p ; hsa-mir-520e ; hsa-mir-520f-3p ; hsa-mir-520a-3p ; hsa-mir-526b-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-519d-3p ; hsa-mir-520d-3p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-548c-3p ; hsa-mir-875-5p ; hsa-mir-302e ; hsa-mir-4282 ; hsa-mir-4720-3p ; hsa-mir-4777-3p ; hsa-mir-2117 ; hsa-mir-4273 ; hsa-mir-4753-3p ; hsa-mir-6739-3p ; hsa-mir-6809-3p ; hsa-mir-7156-5p ; hsa-mir-302b-5p ; hsa-mir-302d-5p ; hsa-mir-4677-5p ; hsa-mir-4804-3p ; hsa-mir-130b-5p ; hsa-mir-3973 ; hsa-mir-30b-5p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-208a/Upstream/1896872; hsa-mir-1185-1/Downstream/73797;
Nearest TSS
ENST00000550708/Upstream/3160; ENST00000554332/Downstream/14353;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/7249, chr14-CpG: 67/Downstream/43759
Upstream sequence
tatttaactatttGTCTCATTTGTGCCTGTGGGATTGTAATCTATAGAGGTGACTGAGTGATGACACAGTCCAAtgcccttgaaagaaaacttttactac
Downstream sequence
ttatattgcctgagagaagggggcttgatgtgccatgcagggccacatggggaagcaccagttttagtcaggagtcacaaggaactaggggaaaaagtag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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