Basic Information
VIS ID
TVIS44020881
Fusion event
HTLV-1-ACTN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
69387402/68920685 (Hg38)
End
69387402/68920685 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
ACTN1
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-193b-3p ; hsa-mir-1-3p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-208a/Upstream/1478755; hsa-mir-1185-1/Downstream/3596135;
Nearest TSS
ENST00000550708/Upstream/30543; ENST00000553944/Downstream/353;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/45582, chr14-CpG: 176/Downstream/57237
Upstream sequence
CAGTCTTCCCAGGGCCCCGGGGAGTCTCGGGGCAGCCTCCAGCCTCCACCAGCCTGTGTCTGCACACCCTTTCCAGCCCATACACAAATCCTCTGCTCCA
Downstream sequence
GGCAACACCGTGCAGTCAGGCCTCTGGATGGGGGAGGTGGCATGCCACACACACAGGACTCCACAGAGCAAGGACGTGGCTAAGCAGGTGCAGGCATGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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