Basic Information
VIS ID
TVIS44020884
Fusion event
HTLV-1-ZFYVE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
73491564/73024856 (Hg38)
End
73491564/73024856 (Hg38)
Orient
+
Location type
UTR5
Target gene
ZFYVE1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-208a/Upstream/507958; hsa-mir-1185-1/Downstream/733891;
Nearest TSS
ENST00000550708/Upstream/37871; ENST00000525161/Downstream/2250;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/97948, chr14-CpG: 25/Downstream/2081
Upstream sequence
AGTGCAAGCAAAGATGTGGTCAAAATTGACTTGGAAGGGTCTTTTATGGCTATCTGAGAGAGGTCTGATGGGTTCACGGTGGTGGGTTCATCGGTTGGAC
Downstream sequence
ATCAGCTACAAAGTTTTGGTAATGAAAGAAAGTGGTCAGGAGCTTTTCAATATAATTCGACCTGAAGTCAGTATTTCAGGGGATACCTAGAATAGAGGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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