Basic Information
VIS ID
TVIS44020885
Fusion event
HTLV-1-NUMB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
73846213/73379505 (Hg38)
End
73846213/73379505 (Hg38)
Orient
-
Location type
Intronic
Target gene
NUMB
miRNAs that regulate target gene
hsa-mir-31-5p ; hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-29c-3p ; hsa-mir-103a-3p ; hsa-mir-146a-5p ; hsa-mir-1277-5p ; hsa-mir-4684-5p ; hsa-mir-107 ; hsa-mir-4738-3p ; hsa-mir-1184 ; hsa-mir-6074 ; hsa-mir-4496 ; hsa-mir-3163 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-509-5p ; hsa-mir-4418 ; hsa-mir-509-3-5p ; hsa-mir-548av-3p ; hsa-let-7c-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-208a/Upstream/862607; hsa-mir-1185-1/Downstream/379242;
Nearest TSS
ENST00000550708/Upstream/12585; ENST00000304061/Downstream/30566;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/133302, chr14-CpG: 55/Downstream/78376
Nearest cancer related gene
NUMB(TSG, No orient, 0)
Upstream sequence
agagaatgaaacaaaccctctaccctcacggtagttgcactttatttggagagactgtcaaaataatgaagaaacaaatacataatatgttgagacatat
Downstream sequence
aaagaaaaatcaagtaggattggagaaaagaaagtgttgggattggggaacagggtagaaaggaggcggctcttctaaataaatagttaagagacggctt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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