Basic Information
VIS ID
TVIS44020896
Fusion event
HTLV-1-TSHR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
81552750/81086406 (Hg38)
End
81552750/81086406 (Hg38)
Orient
+
Location type
Intronic
Target gene
TSHR
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1260a/Upstream/3820116; hsa-mir-1185-1/Downstream/12861820;
Nearest TSS
ENST00000550708/Upstream/7704; ENST00000556031/Downstream/21943;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/131189, chr14-CpG: 147/Downstream/133635
Upstream sequence
gaggagagaggtaggtgatttctgttctcaGAGTTAACTCCATCCTCTCTTTTCCAAGGTCTGTTTCATATTCAGTGTCCTTAGTTGAAATGCCTAGTTG
Downstream sequence
AAAAAACCAGAGAGTTTTTTCTAATTTTGCAAGAATGTCACAACATCTCCAGTCCCAAGTCCCTGATGTCTCTTCTAGCTTTCATTGCACTTATGAAAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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