Basic Information
VIS ID
TVIS44020905
Fusion event
HTLV-1-TTC7B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
91143121/90676777 (Hg38)
End
91143121/90676777 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTC7B
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-9-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1260a/Upstream/13410487; hsa-mir-1185-1/Downstream/3271449;
Nearest TSS
ENST00000550708/Upstream/1659; ENST00000553712/Downstream/1068;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/55325, chr14-CpG: 32/Downstream/81708
Upstream sequence
AGAGAAGCAGATGGAGAGAGAACCTAGTGCTGCATGGCGGGGAGTCCACCTAGGCCCTCCTGCCCCTACCAATTTGCGAAGGGAATGGAGACAAGGGTAG
Downstream sequence
GAATGAGCAGAGGCCTGTCATCTTGGGTTATTTATTCAAAATCCCCTGGGCACCGCAGAACATGATATACGGGATGATCCAAACACTGAAGTCCTGGAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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