Basic Information
VIS ID
TVIS44020932
Fusion event
HTLV-1-OTUD7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
32076450/31784247 (Hg38)
End
32076450/31784247 (Hg38)
Orient
+
Location type
Intronic
Target gene
OTUD7A
miRNAs that regulate target gene
hsa-mir-30c-5p ; hsa-mir-491-3p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-1255b-2-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5582-3p ; hsa-mir-1238-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-153-5p ; hsa-mir-670-3p ; hsa-mir-8080 ; hsa-mir-1197
Nearest miRNA
hsa-mir-1268a/Upstream/719106; hsa-mir-10393/Downstream/2597822;
Nearest TSS
ENST00000557528/Upstream/128908; ENST00000636184/Downstream/86331;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/299462, chr15-CpG: 177/Downstream/85714
Nearby gene
OTUD7A(-128908) ;
Upstream sequence
agaactgtaatataatggagtatgaaaagtttaccaatgtggcttcagattccatgtggcaactaattttaagaaactacttgttgttgaattcagatgt
Downstream sequence
agtgtcaaagatatccacaattacctgaaaagtcaactgaaatactcctcccctttccaactacatagcagtatgaggttagacttgcttctcacactac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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