Basic Information
VIS ID
TVIS44020947
Fusion event
HTLV-1-CTDSPL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.3
Reference genome
GRCh37/hg19
Start
44748800/44456602 (Hg38)
End
44748800/44456602 (Hg38)
Orient
+
Location type
Intronic
Target gene
CTDSPL2
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-100-5p ; hsa-mir-374a-5p ; hsa-mir-18b-3p ; hsa-mir-3157-3p ; hsa-mir-4744 ; hsa-mir-4709-3p ; hsa-mir-3127-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-4699-5p ; hsa-mir-539-5p ; hsa-mir-3918 ; hsa-mir-4761-3p ; hsa-mir-140-3p ; hsa-mir-618 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/662843; hsa-mir-10393/Downstream/261242;
Nearest TSS
ENST00000557528/Upstream/28788; ENST00000561189/Downstream/2401;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/28662, chr15-CpG: 131/Downstream/79837
Upstream sequence
ttctagattttctagtttatttgcatagaggtgtttatagtattctctgatggtagtagtttgtatttctgtggaatcagtgatgatatcccctttgtca
Downstream sequence
ttttttactgcgtctatttgattcttctctcttttcttattagtcttgctagcgtcctgtcaattttgttaatcttttcaaaaaaccagctcctggattc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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