Basic Information
VIS ID
TVIS44020953
Fusion event
HTLV-1-SEMA6D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
48018169/47725972 (Hg38)
End
48018169/47725972 (Hg38)
Orient
-
Location type
Intronic
Target gene
SEMA6D
miRNAs that regulate target gene
hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-130a-5p ; hsa-mir-23c ; hsa-mir-3662 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-4506 ; hsa-mir-7-5p ; hsa-mir-5003-5p ; hsa-mir-8485 ; hsa-mir-3529-3p ; hsa-mir-589-3p ; hsa-mir-8068 ; hsa-mir-1225-5p ; hsa-mir-10b-3p ; hsa-mir-1278 ; hsa-mir-1911-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-3182 ; hsa-mir-361-5p ; hsa-mir-3617-3p ; hsa-mir-374a-3p ; hsa-mir-4303 ; hsa-mir-4490 ; hsa-mir-452-5p ; hsa-mir-4659a-3p ; hsa-mir-4659b-3p ; hsa-mir-4676-3p ; hsa-mir-4682 ; hsa-mir-513a-5p ; hsa-mir-6736-3p ; hsa-mir-892c-3p ; hsa-mir-4433a-3p ; hsa-mir-4433b-3p ; hsa-mir-4496 ; hsa-mir-4722-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-6165
Nearest miRNA
hsa-mir-10393/Upstream/2292843; hsa-mir-11181/Downstream/1443098;
Nearest TSS
ENST00000557528/Upstream/7483; ENST00000559196/Downstream/33751;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/7125, chr15-CpG: 53/Downstream/451838
Upstream sequence
GTTAATAGTTATGTGACAGATAGTCTTAGAGACGAATCTTAAGTCTGAAGAATCACTGCCAATTAAAGATCAATCAGAAATTATAAAATAGGTCAATAGG
Downstream sequence
GAAAAAGGATTAAGCATATACAAATTCAATGTTGGGAACTCTTCAGGAATATTCGAGTGACATAAAGCAGAGAACCTGTTTAGTTTAGTAATCGGTCTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate