Basic Information
VIS ID
TVIS44020955
Fusion event
HTLV-1-CEP152 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
49098330/48806133 (Hg38)
End
49098330/48806133 (Hg38)
Orient
-
Location type
Intronic
Target gene
CEP152
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-877-3p ; hsa-mir-454-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-18a-3p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-197-3p
Nearest miRNA
hsa-mir-10393/Upstream/3373004; hsa-mir-11181/Downstream/362937;
Nearest TSS
ENST00000557528/Upstream/16811; ENST00000560490/Downstream/4461;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/159753, chr15-CpG: 16/Downstream/4401
Upstream sequence
ACAGGCAGTACCCTATTGCTTCATTTTTTTTTAATATCAGAAATCCAAATATCATGCTTTACAAGAAGAAGGCCCCTAAATCATGAGTGAATGACTACTA
Downstream sequence
CCCAGAAACCATTTACAATTCAGTCAATGCCATAGAGTGCACAACAAAATATAAGTCTTAAATGTCCTCCTCTTAAGCTTGATAAAATCAGGTTCTGGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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