Basic Information
VIS ID
TVIS44020968
Fusion event
HTLV-1-MEGF11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
66210091/65917753 (Hg38)
End
66210091/65917753 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
MEGF11
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10393/Upstream/198421; hsa-mir-11181/Downstream/122480;
Nearest TSS
ENST00000557528/Upstream/2155; ENST00000532293/Downstream/4622;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/47498, chr15-CpG: 30/Downstream/64443
Upstream sequence
GCACCACCTCTTCCCCATCCAAACTCGGGCTGCTCCTTGTGCAGGTGCTAATGGAGTGTTAAGTCTCAGAATTCATAGCATTAATGGTACTATCAACAAT
Downstream sequence
ATCAGTACCTTTGATACCAGCAGTTAATACCAATGATCAATCCTAATAATCCATCATGTTAGCTATAGAGCTAAATGGGGCTCATTCCTACATGCAGAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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