Basic Information
VIS ID
TVIS44020976
Fusion event
HTLV-1-TLE3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
70356492/70064153 (Hg38)
End
70356492/70064153 (Hg38)
Orient
+
Location type
Intronic
Target gene
TLE3
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-505-3p ; hsa-mir-196b-5p ; hsa-mir-222-3p ; hsa-mir-34a-5p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-18a-5p ; hsa-mir-1260b ; hsa-mir-6858-5p ; hsa-mir-8085 ; hsa-mir-4689 ; hsa-mir-6731-5p ; hsa-mir-765 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-7160-5p ; hsa-mir-6133 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6760-5p ; hsa-mir-4786-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-6873-5p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-6739-5p ; hsa-mir-767-5p ; hsa-mir-648 ; hsa-mir-1911-3p ; hsa-mir-595 ; hsa-mir-5583-5p ; hsa-mir-4311 ; hsa-mir-3129-3p ; hsa-mir-141-5p ; hsa-mir-3163 ; hsa-mir-548c-3p ; hsa-mir-744-5p
Nearest miRNA
hsa-mir-10393/Upstream/1262228; hsa-mir-11181/Downstream/15219;
Nearest TSS
ENST00000557528/Upstream/5338; ENST00000558226/Downstream/10442;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/30069, chr15-CpG: 409/Downstream/31437
Upstream sequence
CTCTCAGAGTATCACCTCTCATAtgaaacggagttagagctcatttagcccaagctcttcatttgacaaatggcagacctaaagcctggagagaggaagg
Downstream sequence
gcttccacaaCTGAAGGTCACTCTCAACAGGTGACGACAGCAGCTCCCATTTTATGACAGTAGCTACCCCTCACCCTGCCACTGGCTCTGGACTAAGACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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