Basic Information
VIS ID
TVIS44021007
Fusion event
HTLV-1-VPS35L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
19636682/19625360 (Hg38)
End
19636682/19625360 (Hg38)
Orient
-
Location type
Intronic
Target gene
VPS35L
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-30a-5p ; hsa-mir-1180-3p
Nearest miRNA
hsa-mir-1225/Upstream/1130784; hsa-mir-11401/Downstream/1880689;
Nearest TSS
ENST00000527434/Upstream/17571; ENST00000544275/Downstream/22487;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/69294, chr16-CpG: 84/Downstream/92512
Upstream sequence
tgaaatgggagaatagagcccctgcttcaagggtggttgggagaggtaagatcgtgagtgcaaagtgcttctcaccatggctggtgggcactaagctctA
Downstream sequence
GCCCAGTGTTTGTTGCTGATATTACTAAGTGCACCTTGGGCACCTCTTAAAATGGGGAAGAATGTGGGGTTACAGAAGAGGTGGGGAGCAGAGTAATTAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate