Basic Information
VIS ID
TVIS44021020
Fusion event
HTLV-1-HMOX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4529890/4479889 (Hg38)
End
4529890/4479889 (Hg38)
Orient
-
Location type
Intronic
Target gene
HMOX2
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-1225/Upstream/994420; hsa-mir-11401/Downstream/191429;
Nearest TSS
ENST00000527434/Upstream/3430; ENST00000575129/Downstream/15874;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/2963, chr16-CpG: 119/Downstream/57946
Upstream sequence
gtgtggtggcacaatctcagctcactgcaacctccgcctcctgggttcaagcgattctccagcctcagtctcctgagtagctgggattacaggcgtatgc
Downstream sequence
caccatgcctggctaatttttgtatttttagtagagatgaggtttcactatgttggccgggctggtctcctactcctgacctcaggtgatccgtccacct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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