Basic Information
VIS ID
TVIS44021035
Fusion event
HTLV-1-CHD9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
53175939/53142027 (Hg38)
End
53175939/53142027 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHD9
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-155-5p ; hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-let-7e-5p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-22-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-376a-5p ; hsa-mir-181d-5p ; hsa-mir-376a-2-5p ; hsa-mir-944 ; hsa-mir-664a-3p ; hsa-mir-2052 ; hsa-mir-1193 ; hsa-mir-4262 ; hsa-mir-3607-3p ; hsa-mir-3668 ; hsa-mir-3686 ; hsa-mir-3935 ; hsa-mir-4663 ; hsa-mir-4682 ; hsa-mir-8077 ; hsa-mir-433-3p ; hsa-mir-7154-5p ; hsa-mir-34b-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6794-3p ; hsa-mir-627-3p ; hsa-mir-4639-3p ; hsa-mir-342-3p ; hsa-mir-548c-3p ; hsa-mir-3163 ; hsa-mir-628-5p ; hsa-mir-7641 ; hsa-mir-3171 ; hsa-mir-139-5p
Nearest miRNA
hsa-mir-1225/Upstream/2399650; hsa-mir-11401/Downstream/3103493;
Nearest TSS
ENST00000527434/Upstream/10893; ENST00000562785/Downstream/13976;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10101, chr16-CpG: 37/Downstream/231388
Upstream sequence
GTTGAATTCAGGCAACATTTCAATGTAGTGGAAACATAGATTACCTATGAGAGTGGCAAATAAGAGTGGAGGGGCATTGATAACTTTGGGAAAGGAATAA
Downstream sequence
AATAGGAAGTACATATGTTGAGAGGCAAAGATAAATTTAGATATCATAAAATATGATATTGTTGATTGGTATAACATTTTTAATTTTTTAAATGAAAATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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