Basic Information
VIS ID
TVIS44021036
Fusion event
HTLV-1-FTO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
54139589/54105677 (Hg38)
End
54139589/54105677 (Hg38)
Orient
-
Location type
Intronic
Target gene
FTO
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-4738-5p ; hsa-mir-6134 ; hsa-mir-6807-5p ; hsa-mir-4266 ; hsa-mir-4641 ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-8060 ; hsa-mir-4768-3p ; hsa-mir-4779 ; hsa-mir-4695-5p
Nearest miRNA
hsa-mir-1225/Upstream/3363300; hsa-mir-11401/Downstream/2139843;
Nearest TSS
ENST00000527434/Upstream/35781; ENST00000637049/Downstream/44013;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/401354, chr16-CpG: 21/Downstream/16364
Upstream sequence
ATTATTAGGAAAGTAAGAAGCAGTGCTGTGGATTGACATTATTCGGGACATTTAAACATTGTACAAAATGTAATTGTTATTTTAATTAGGAGTTGTTCTC
Downstream sequence
CTCTTTCCCACTGAAGAATTCCCTCTTAGGAGTTCATTTCTGTTATCTCTTCAGTGGCCCATGCTTGGTAATATTTCTCCATCAAGTTCTAGTCtgtgtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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