Basic Information
VIS ID
TVIS44021063
Fusion event
HTLV-1-SLC12A4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67985023/67951120 (Hg38)
End
67985023/67951120 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
SLC12A4
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-155-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1225/Upstream/748725; hsa-mir-11401/Downstream/282306;
Nearest TSS
ENST00000527434/Upstream/699; ENST00000569289/Downstream/347;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/14605, chr16-CpG: 79/Downstream/17056
Upstream sequence
TCACGAAGGTCCCCAGAGCGGTTTGAGCCAGCCATGATGCCTCCAAAAACAGATGAGACTCCCTCAGGGGCTCCCCGGGATTGGGGACAGGGCTGGGTGG
Downstream sequence
GTAGGCAGGCAGGGCTCACCTGTTACAGAAGGGAAGAAGATGCCGACCAGCACGGTGAAGGATGTGGCGATGTCAGCGACCACGTACAGAGGCAGGCTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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