Basic Information
VIS ID
TVIS44021065
Fusion event
HTLV-1-SMPD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
68393347/68359444 (Hg38)
End
68393347/68359444 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA16B
Target gene
SMPD3
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1225/Upstream/125945; hsa-mir-11401/Downstream/1206364;
Nearest TSS
ENST00000527434/Upstream/5115; ENST00000619354/Downstream/4249;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/48101, chr16-CpG: 88/Downstream/11560
Upstream sequence
AGCAGGATGCTCGCCCTCAGCAGCCCCTTCCTGGCTCTGGACTCTGGAGGGGCAGGGCTTGGGCCCGGGCAGACGGTGCTTCCCAGGCCAGGTGAGTTCA
Downstream sequence
GACAGGCCAGTGTCACAAGGACGCACGTCCTAGCGCCAGGCTCCCTGGGCTCTGCAGCGTTGTCTGCCCCAGCACAGGGCCAGGCATCTGGCTGGCTGCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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