Basic Information
VIS ID
TVIS44021076
Fusion event
HTLV-1-MAF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
79500242/79466345 (Hg38)
End
79500242/79466345 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16D
Target gene
MAF
miRNAs that regulate target gene
hsa-mir-621 ; hsa-mir-302c-5p ; hsa-mir-6798-3p ; hsa-mir-3143 ; hsa-mir-4640-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-618 ; hsa-mir-3942-3p ; hsa-mir-5100 ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-10b-3p ; hsa-mir-205-3p ; hsa-mir-6514-5p ; hsa-mir-4802-5p ; hsa-mir-451b ; hsa-mir-486-3p ; hsa-mir-212-5p ; hsa-mir-147a ; hsa-mir-210-3p ; hsa-mir-3151-5p ; hsa-mir-342-5p ; hsa-mir-3621 ; hsa-mir-3650 ; hsa-mir-3656 ; hsa-mir-3911 ; hsa-mir-4447 ; hsa-mir-4455 ; hsa-mir-4472 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-491-5p ; hsa-mir-574-5p ; hsa-mir-608 ; hsa-mir-644a ; hsa-mir-6737-5p ; hsa-mir-6742-5p ; hsa-mir-6747-5p ; hsa-mir-6796-5p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6867-5p
Nearest miRNA
hsa-mir-1225/Upstream/2597326; hsa-mir-11401/Downstream/1918673;
Nearest TSS
ENST00000527434/Upstream/236892; ENST00000569938/Downstream/39258;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1366176, chr16-CpG: 44/Downstream/123249
Nearby gene
MAF(-127503) ;
Nearest cancer related gene
MAF(OG, No orient, 0)
Upstream sequence
AGCACAGGTAACTGAAGGGCACCTGGCAGGCTGCAGGGTGACATGCTCTGAAATCTGTGTGAATGAAGGATGACTCATGGGTTTAAATGATGTCCATTAA
Downstream sequence
TGCCATCCTGAAAATGAAATTGCCTCACTCTCAGTAATGGTGTTCTTCAGGTTTCATCTTGGCAGACTGGTTAGGGCTTTGTGTTGAAACGAGCAAAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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