Basic Information
VIS ID
TVIS44021098
Fusion event
HTLV-1-JPH3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
87681960/87648354 (Hg38)
End
87681960/87648354 (Hg38)
Orient
+
Location type
Intronic
Target gene
JPH3
miRNAs that regulate target gene
hsa-mir-6749-3p ; hsa-mir-202-5p ; hsa-mir-642a-5p ; hsa-mir-6845-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-1910-5p ; hsa-mir-455-3p
Nearest miRNA
hsa-mir-12128/Upstream/1729938; hsa-mir-11401/Downstream/186238;
Nearest TSS
ENST00000527434/Upstream/45449; ENST00000563609/Downstream/5208;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/3300, chr16-CpG: 29/Downstream/6505
Upstream sequence
AAAAAAGGAGGGAAGAGAGTCTGCCGCCCTGGAGAGTGAAGCTGATGAATGGCTGGCTCAGGCGCCCACAGCCCCAGGGCCAACCCTCCACTGGAGCATG
Downstream sequence
AGAGCGGCCGCACCACGTGGGCTGAGGAGTGACTGGCCCCGGGCGGGCTCCTGCCACTATCACAGTCGAGAGATGCGAGGGAGTTGTAGGGCAGCTGGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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