VISDB - VIS Detail

Basic Information

VIS ID

TVIS44021099

Fusion event

HTLV-1-KLHDC4 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

29186194

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr16

Cytoband

q24.2

Reference genome

GRCh37/hg19

Start

87737364/87703758 (Hg38)

End

87737364/87703758 (Hg38)

Orient

+

Location type

Intronic

Target gene

KLHDC4

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-6794-3p ; hsa-mir-505-3p ; hsa-mir-874-5p ; hsa-mir-5699-5p ; hsa-mir-6837-3p ; hsa-mir-335-5p

Nearest miRNA

hsa-mir-12128/Upstream/1785342; hsa-mir-11401/Downstream/130834;

Nearest TSS

ENST00000527434/Upstream/1167; ENST00000563687/Downstream/4629;

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/457, chr16-CpG: 22/Downstream/1253

Nearby gene

KLHDC4(-4054) ;

Upstream sequence

TGCAGCCAGTGGGGGCTTGGAAGGGCTCTGAAGGTTGAGACAAGGAAAACGGGCGTGAGCTGGACTCAGGGAAGCCGGGTCACCGTGGTACCTGCACTGT

Downstream sequence

GGCCCTTGGCCATGACAGTGTGTCAGCTTCCGGCAGGGACTGCTTGTGTGCCTCGGGACACCAGTGACCAGGTGTGGCCAGGCCCCAGATGGCATTGCTG

Reference

Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.