Basic Information
VIS ID
TVIS44021104
Fusion event
HTLV-1-GAS7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10093046/10189729 (Hg38)
End
10093046/10189729 (Hg38)
Orient
+
Location type
Intronic
Target gene
GAS7
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-1255b-5p ; hsa-mir-6744-5p ; hsa-mir-1255a ; hsa-mir-1287-5p ; hsa-mir-4487 ; hsa-mir-450b-5p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-3124-3p ; hsa-mir-6837-3p
Nearest miRNA
hsa-mir-1253/Upstream/2002725; hsa-mir-10226/Downstream/1892170;
Nearest TSS
ENST00000595228/Upstream/75176; ENST00000609088/Downstream/8822;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/284707, chr17-CpG: 142/Downstream/7988
Upstream sequence
tattttcccccAAATAGTCACATGGCTggctgggcacagtggctcaagcctgtaatcccagcactttgggaggccaaggagggtggatcacttgaggcca
Downstream sequence
ggagttggagaccagcctggccaacatggcaaaaccctatctctactaaaaatacaaaaattagccggctgtggtggcgggtgcctatagtcccaactac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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