Basic Information
VIS ID
TVIS44021107
Fusion event
HTLV-1-chr17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
12100029/12196712 (Hg38)
End
12100029/12196712 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/114716; hsa-mir-10226/Downstream/720556;
Nearest TSS
ENST00000595228/Upstream/72413; ENST00000585228/Downstream/4888;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/175158, chr17-CpG: 70/Downstream/468638
Nearby gene
MAP2K4(+52881) ;
Nearest cancer related gene
MAP2K4(TSG, +52881) ;
Upstream sequence
GCCTGGAATTCTTACTAGGCTTAGGTGAAGAGAAAATATCCCTCCAACAAGGGACCTCACGACCCCATCTCAAAGACCATTTCTCCAACTTTTCCAACTT
Downstream sequence
TAACTCTAGTTTTTGGGCAGGTCAAGGTGGGCTGTGGGCCACAAAATCATTCTATTACTTCCTTTGTAGGTCCTGCAGAGTTGGTCAAAGGGAAAGCCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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