Basic Information
VIS ID
TVIS44021122
Fusion event
HTLV-1-FAM222B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
27133413/28806395 (Hg38)
End
27133413/28806395 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM222B
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-181a-5p ; hsa-mir-142-3p ; hsa-mir-3678-3p ; hsa-mir-6727-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-2467-3p ; hsa-mir-202-3p ; hsa-mir-4462 ; hsa-mir-6730-5p ; hsa-mir-3158-5p ; hsa-mir-4787-5p ; hsa-mir-759 ; hsa-mir-3677-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-488-3p ; hsa-mir-4500 ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7c-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-98-5p ; hsa-let-7d-5p ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-130a-5p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-23b-3p
Nearest miRNA
hsa-mir-1180/Upstream/445661; hsa-mir-10226/Downstream/54974;
Nearest TSS
ENST00000595228/Upstream/29224; ENST00000578001/Downstream/5829;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/61843, chr17-CpG: 21/Downstream/36113
Upstream sequence
CTGTGAATCTAAGGAATGAACTCTTAACTAGAGTCTTGTCCATATCTTGGTAAAGATGCCCTCTGCCCTTTTCAGTTAGGCCGCAATGTAACAAACTCAG
Downstream sequence
TCCATGACTGAATTTAATCTAACCAGCCCAGTATTTCCTTCCTGGGATCCACCAGCACCAAATATAATAAAACTTCAATTTGGAAgtcgggcaccacggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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