Basic Information
VIS ID
TVIS44021137
Fusion event
HTLV-1-RFLNB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
291078/441287 (Hg38)
End
291078/441287 (Hg38)
Orient
+
Location type
UTR3
Target gene
RFLNB
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-192-5p ; hsa-mir-3157-5p ; hsa-mir-4691-3p ; hsa-mir-888-5p ; hsa-mir-1827 ; hsa-mir-3664-3p ; hsa-mir-3929 ; hsa-mir-3934-3p ; hsa-mir-4419b ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4478 ; hsa-mir-4649-3p ; hsa-mir-4695-5p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-485-5p ; hsa-mir-5192 ; hsa-mir-665 ; hsa-mir-6808-5p ; hsa-mir-6884-5p ; hsa-mir-6893-5p ; hsa-mir-7160-5p ; hsa-mir-767-3p ; hsa-mir-940
Nearest miRNA
hsa-mir-10226/Downstream/581189;
Nearest TSS
ENST00000595228/Upstream/27094; ENST00000571282/Downstream/4652;
Nearest CpG islands
chr17-CpG: 22/Target, None/Upstream, None/Downstream
Upstream sequence
ACTGTGGGTCCCAGGGTGGCCCCTCCCTGGGTCCCAGCCGAGCTTCAGCCCGGCAAGCTCAGACCACGGGTGGACTGCAGGCCCCGTCCACAGGGCGTCG
Downstream sequence
ATGCATTGGGGCACAGCGGACTGATGCTGTTGTCTGCAGAGGACAGCGTGGCTCTCCAGGACTCCAGCGACTGCGCACGACGGCGATTGTCGCTGCACCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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