Basic Information
VIS ID
TVIS44021154
Fusion event
HTLV-1-TEX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
62247366/64170006 (Hg38)
End
62247366/64170006 (Hg38)
Orient
-
Location type
Intronic
Target gene
TEX2
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-26b-5p ; hsa-mir-423-5p
Nearest miRNA
hsa-mir-10226/Upstream/1225694; hsa-mir-1250/Downstream/330768;
Nearest TSS
ENST00000595228/Upstream/13772; ENST00000617071/Downstream/18448;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/23242, chr17-CpG: 92/Downstream/92437
Upstream sequence
CCAAGGGAGGCTACAGTAAAAACGTCAGTGAGAATTCTCTCTGCATGCTAATGGGCTATTCTGGCCTACCTGGCTCATTCCTCTTTTTTTACCAAACTCC
Downstream sequence
TGTGTACTAAATTTTCCCTGTCAAGATCCTTTTAAAACCGTATTTATGGTTTATGTGACATAAGAGATACAAATCCTTACATCATCATCATCATCATGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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