Basic Information
VIS ID
TVIS44021160
Fusion event
HTLV-1-PITPNC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
65617849/67621733 (Hg38)
End
65617849/67621733 (Hg38)
Orient
-
Location type
Intronic
Target gene
PITPNC1
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-335-5p ; hsa-mir-142-3p ; hsa-mir-7-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-4672 ; hsa-mir-5011-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-6768-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-369-3p ; hsa-mir-548v ; hsa-mir-548d-3p ; hsa-mir-548au-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-6516-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-488-3p ; hsa-mir-657 ; hsa-mir-4635 ; hsa-mir-3665 ; hsa-mir-4678 ; hsa-mir-935 ; hsa-mir-5003-3p ; hsa-mir-140-3p ; hsa-mir-497-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-10226/Upstream/150148; hsa-mir-1250/Downstream/802718;
Nearest TSS
ENST00000595228/Upstream/68547; ENST00000581966/Downstream/96100;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/242718, chr17-CpG: 43/Downstream/95919
Upstream sequence
tttttccaaggcacagtgttgaacacacagtaggtgcttaaccaatatttgccaattcattgaatGGTGGGCATTCGGCCTCTTCATCTCTAGAGTGCTG
Downstream sequence
TCCTTAAGTACAGTAATTCTATCTTAAGAACAAATAACAGTTACCCAACTCTGTCTTCTGCAAAACAGAAAAAAGAATAGAGACCAAAAATGGTTCTGAg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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