Basic Information
VIS ID
TVIS44021172
Fusion event
HTLV-1-TSEN54 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
73518053/75521972 (Hg38)
End
73518053/75521972 (Hg38)
Orient
+
Location type
Exonic
Target gene
TSEN54
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-484 ; hsa-mir-8073 ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-3202 ; hsa-mir-7515 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-1178-5p ; hsa-mir-6760-5p ; hsa-mir-9500 ; hsa-mir-6510-5p ; hsa-mir-6794-3p
Nearest miRNA
hsa-mir-10226/Upstream/23344; hsa-mir-1250/Downstream/262549;
Nearest TSS
ENST00000595228/Upstream/5002; ENST00000579449/Downstream/21;
Nearest CpG islands
chr17-CpG: 32/Target, None/Upstream, None/Downstream
Upstream sequence
GGGCCCCAGCCCTGGCCCGGCCAGGGAGGGGGTGGGGTGCAGCTGGGAGAGTGGCAGAGCCGAGAACGGAGTCACGGGAGCCGGTAAGCGGCGCTGGAAC
Downstream sequence
TTCGAGCAGATCTCCTTCCCCAACATGGCTTCAGACAGCCGCCACACCCTTCTGCGCGCCCCAGCCCCAGAGCTGCTCCCGGCCAACGTGGCTGGGCGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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