Basic Information
VIS ID
TVIS44021184
Fusion event
HTLV-1-NTN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
9109124/9205807 (Hg38)
End
9109124/9205807 (Hg38)
Orient
+
Location type
Intronic
Target gene
NTN1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-1296-5p ; hsa-mir-423-3p ; hsa-mir-486-3p ; hsa-mir-6780b-5p ; hsa-mir-4271 ; hsa-mir-4725-3p ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-2467-3p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6805-5p ; hsa-mir-6783-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-4779 ; hsa-mir-6873-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4749-3p ; hsa-mir-4313 ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6887-3p ; hsa-mir-361-3p ; hsa-mir-6769a-3p
Nearest miRNA
hsa-mir-1253/Upstream/1018803; hsa-mir-10226/Downstream/2876092;
Nearest TSS
ENST00000595228/Upstream/26689; ENST00000579641/Downstream/39090;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/42736, chr17-CpG: 72/Downstream/33856
Upstream sequence
CTCTGTGTATGGAAAGAGACCCCTCTGTCCTGTGCTGGAGTGGAAGGCAGCTGTGTTAGGGAATGGGCCCCCACCGGCCAGTGACTTTGGATGCTGAACA
Downstream sequence
CTTGTACCTCTGTTTTCTCCTGTGTGTAATGGCCATGGCCGTCCTAATACCACCCGAACTGCCTCTTCCTATGTGGCTGTGCAGCTTACTCGGGACATTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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