Basic Information
VIS ID
TVIS44021216
Fusion event
HTLV-1-MOCOS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
33806783/36226820 (Hg38)
End
33806783/36226820 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
MOCOS
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-526b-5p ; hsa-mir-4320 ; hsa-mir-4667-3p ; hsa-mir-541-5p ; hsa-mir-6865-3p ; hsa-mir-6086 ; hsa-mir-6854-3p ; hsa-mir-377-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-5691 ; hsa-mir-6805-3p ; hsa-mir-3944-5p ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-3194-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-4733-3p ; hsa-mir-1226-3p ; hsa-mir-1911-3p
Nearest miRNA
hsa-mir-1-2/Upstream/292678; hsa-mir-122/Downstream/1430315;
Nearest TSS
ENST00000575820/Upstream/39301; ENST00000588132/Downstream/30027;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/38638, chr18-CpG: 194/Downstream/69944
Upstream sequence
tttttggtgtgtagttatttcgaggcttacataaaatatcttagagttataacggtctattttaagctgacagcaagtttaatcacatacataactctac
Downstream sequence
actttaagctttgctccccatactttacgtatggttgtcaggatttacatctattcatgatgtgTATCttttttttttttttttgagacagggtcttgct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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