Basic Information
VIS ID
TVIS44021230
Fusion event
HTLV-1-PSTPIP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
43638732/46058766 (Hg38)
End
43638732/46058766 (Hg38)
Orient
-
Location type
Intronic
Target gene
PSTPIP2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-1-2/Upstream/1088600; hsa-mir-122/Downstream/1321730;
Nearest TSS
ENST00000575820/Upstream/18479; ENST00000591098/Downstream/13491;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/30222, chr18-CpG: 80/Downstream/13064
Upstream sequence
CTAGTTTTTTAAGGTACCAATAAAAATGAAAAATAAATAGCTCATGGAATCCATAGGCGGTTCTCTCTGCTTAAAGGCAGGGGTGCTGAGGAGAGGTCTC
Downstream sequence
GCTGCAAGATAATTGTCATTAGGCAGGTCCTGTCACCAGCGGGGTGGGACCCTCTGTGTCCTCAAGGGAATGGTTGTGGCCTTGCCACAGGCAGGTGGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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