Basic Information
VIS ID
TVIS44021235
Fusion event
HTLV-1-ACAA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
47321959/49795589 (Hg38)
End
47321959/49795589 (Hg38)
Orient
-
Location type
Intronic
Target gene
ACAA2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-186-5p ; hsa-mir-6776-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6844 ; hsa-mir-7977 ; hsa-mir-143-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6499-3p ; hsa-mir-9-5p ; hsa-mir-5693 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-1-2/Upstream/308167; hsa-mir-122/Downstream/330910;
Nearest TSS
ENST00000575820/Upstream/8970; ENST00000615535/Downstream/15942;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/233431, chr18-CpG: 60/Downstream/17452
Upstream sequence
TCCCATGCCTATGGCCACTTACACAGGATAATTATACTACTAGAGGTCTGCTGAGATAGATAGAATCTAATTTCATATGGGTTAAAATGTCAAAACTAAC
Downstream sequence
CACCAAAATAGAGTTTTGAAATAGTTTACAAACTTCTAATCATTCATATCTTGCCAATCCTCATCAACGAAATTGGCTTCAAAATTAGTTTTCTCTCCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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