Basic Information
VIS ID
TVIS44021236
Fusion event
HTLV-1-ME2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
48434372/50908002 (Hg38)
End
48434372/50908002 (Hg38)
Orient
+
Location type
Intronic
Target gene
ME2
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-1228-3p ; hsa-mir-1273g-3p ; hsa-mir-194-5p ; hsa-mir-4490 ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-766-3p ; hsa-mir-7703
Nearest miRNA
hsa-mir-1-2/Upstream/781439; hsa-mir-122/Downstream/2329099;
Nearest TSS
ENST00000575820/Upstream/12155; ENST00000639663/Downstream/187;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/28389, chr18-CpG: 62/Downstream/59904
Upstream sequence
ctgaccaatactgacatcagtcttacaaagttttgaaagcctgggcaaaaataatatgtcattgatttttcaaatttgcatttAAATTATATTTTGAAGA
Downstream sequence
ACAATGTCATTGCTACCCCAGTAAGTAATAATTTTTAATCCTTTTATTTCTCCTCTTTAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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