Basic Information
VIS ID
TVIS44021243
Fusion event
HTLV-1-TCF4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
52966766/55299535 (Hg38)
End
52966766/55299535 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
TCF4
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-130b-3p ; hsa-mir-19b-3p ; hsa-let-7e-5p ; hsa-mir-203a-3p ; hsa-mir-452-5p ; hsa-mir-126-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-155-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1-2/Upstream/2062345; hsa-mir-122/Downstream/179686;
Nearest TSS
ENST00000575820/Upstream/23864; ENST00000587660/Downstream/3091;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/339917, chr18-CpG: 80/Downstream/288287
Nearest cancer related gene
TCF4(TSG, No orient, 0)
Upstream sequence
GGGAGCATGTTTCTGCTTTTTTTTTTTTTTTTTTGGGTCTGGTTTGCTTGTTTTCAGTTTAAAAGAAGGAAGATGTTAATGGCAGCATTTACTCATGAGA
Downstream sequence
TACCACATTATTGTTTCAAATGGTATAAATTCCTAATTGTGAGTAATATTTTGAAATGCAATAGCCAAAGTGAAAAAAGTCAAAACCTCATGGGCTGCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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