Basic Information
VIS ID
TVIS44021257
Fusion event
HTLV-1-L3MBTL4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
5985906/5985907 (Hg38)
End
5985906/5985907 (Hg38)
Orient
+
Location type
Intronic
Target gene
L3MBTL4
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-3976/Upstream/145074; hsa-mir-1-2/Downstream/388454;
Nearest TSS
ENST00000575820/Upstream/29806; ENST00000577935/Downstream/39184;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/89657, chr18-CpG: 22/Downstream/298468
Nearest cancer related gene
L3MBTL4(TSG, No orient, 0)
Upstream sequence
GACAAAAAACAGAGATCACACACAGTAGAAGTGAGGGATGGGGATGATGCTACAAATGGACCAGGAGAGAAGCTAATTCAAAGGAGGTATTTTGTGGTTG
Downstream sequence
GGATCTTGGAGAGGGATGCTGTAGAGGGTCAGAGGGCAACAGCAGGTATGACTCTGGGCAGGTGTGTCTAGGACCAGCAACCAGGGGTGCTGAGCAAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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