Basic Information
VIS ID
TVIS44021271
Fusion event
HTLV-1-CNDP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
72238350/74571115 (Hg38)
End
72238350/74571115 (Hg38)
Orient
+
Location type
Intronic
Target gene
CNDP1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-5698 ; hsa-mir-653-3p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3622b-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-5693 ; hsa-mir-718 ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6084 ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-891b ; hsa-mir-4772-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1281 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-660-3p ; hsa-mir-4485-5p ; hsa-mir-1270 ; hsa-mir-129-5p ; hsa-mir-1304-3p ; hsa-mir-139-3p ; hsa-mir-3664-5p ; hsa-mir-4294 ; hsa-mir-4531 ; hsa-mir-4639-3p ; hsa-mir-620 ; hsa-mir-6794-3p ; hsa-mir-7850-5p
Nearest miRNA
hsa-mir-1-2/Upstream/1717733;
Nearest TSS
ENST00000575820/Upstream/3961; ENST00000578498/Downstream/3649;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/74311, chr18-CpG: 136/Downstream/26166
Upstream sequence
taGGAAATCCAGTCCCCATGACTGAGAAACACAGAAAGTGAAGTCAGGTCTGGATGTTGCCTACCTGAGTTCTGAGGGACACACGCAGATATGTATTTCA
Downstream sequence
CCATGTGAAATGCTTACACTAAAGGAACCAAGGCAGGAAGTATATCTCTTACCTTTTATCTACTCTGCAGGTGAAATGCAGAGACCAGGATTTTCACTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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