Basic Information
VIS ID
TVIS44021280
Fusion event
HTLV-1-PTPRM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
8370281/8370283 (Hg38)
End
8370281/8370283 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTPRM
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-205-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-580-3p ; hsa-mir-4753-3p ; hsa-mir-452-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-1279 ; hsa-mir-130b-5p ; hsa-mir-4461 ; hsa-mir-1264
Nearest miRNA
hsa-mir-3976/Upstream/1995858; hsa-mir-1-2/Downstream/2389301;
Nearest TSS
ENST00000575820/Upstream/3249; ENST00000583153/Downstream/650;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/2682, chr18-CpG: 177/Downstream/238482
Upstream sequence
CTTACCAAAAAAAAAAAAAAAAATACAATTTGCTAGGAGAATTTCAAAAATATGACAGTGGAGTGCTTCAGTGCTCAGAAATGAGGGAAATCAAATGCCC
Downstream sequence
CTTGCATGCAAAATTCTTCCACCTGAGATTAGTTAGAGGCTTCAGACAATATGGAAAGACAATTTCAGATTTTAGGAAGTTTTGTTTATTGAATTTATTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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