Basic Information
VIS ID
TVIS44021282
Fusion event
HTLV-1-ARHGAP45 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1071051/1071052 (Hg38)
End
1071051/1071052 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ARHGAP45
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1302-11/Upstream/257399; hsa-let-7e/Downstream/745107;
Nearest TSS
ENST00000633603/Upstream/3554; ENST00000592335/Downstream/169;
Nearest CpG islands
chr19-CpG: 100/Target, None/Upstream, None/Downstream
Upstream sequence
atggttgtggggTCCACCCCACAGCTTGGGGACCCGCGTTCAGGCAGCTAGGAGGGGACCCACATGGACGGTGCCACCCCGACACTTCCCGGGCTTCCTC
Downstream sequence
GTTCCCGGGCTTCAGGTCTGGGCCTCAGTTTCCCTGCCCGTCCTCGACCCTCCCCACCTCGAAGCTCTGCGGTTAAGGAAGGACCCAGGCTGGGGCGAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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