Basic Information
VIS ID
TVIS44021293
Fusion event
HTLV-1-DDX49 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
19038921/18928112 (Hg38)
End
19038921/18928112 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
DDX49
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-25-3p ; hsa-mir-3177-3p
Nearest miRNA
hsa-mir-10395/Upstream/541478; hsa-let-7e/Downstream/506951;
Nearest TSS
ENST00000633603/Upstream/368; ENST00000601106/Downstream/4935;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8268, chr19-CpG: 21/Downstream/1272
Upstream sequence
AAGCAGCTGATCCTGGAGGGGAAGGTGAGGGCCGAGCCCGCAGGTAGGGGGTGGGTGGCCAGGTTCCCTGGCGGGGGCCGCCAGCTCAGCCATCCCCTGG
Downstream sequence
TCCTCCCTGTGCCAGGACCCTGACCTGGAGGCCAAGCGCAAGGCTGAGCTGGCCAAGATCAAGCAGAAGAACCGGCGCTTCAAGGAGAAGGTGGAGGAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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