Basic Information
VIS ID
TVIS44021294
Fusion event
HTLV-1-ZNF253 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
19984760/19873951 (Hg38)
End
19984760/19873951 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF253
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-4776-3p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-3124-3p ; hsa-mir-1914-5p ; hsa-mir-3163 ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-376b-3p ; hsa-mir-376a-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-10395/Upstream/438793; hsa-let-7e/Downstream/525321;
Nearest TSS
ENST00000633603/Upstream/8033; ENST00000640599/Downstream/4530;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/12897, chr19-CpG: 25/Downstream/27150
Upstream sequence
GTTGTGACTTGTGATGTCTACACCTGTAGGGATATTCATGAACAGAAGAATTGTTATTATAATTAAtttttggttttttgagatagagtctctgtcgccc
Downstream sequence
aggatggagtgcaatggcgggatctcagctaactgaaacctcggcctcccgggttcaagtgatactcctgtctcagcctccagagtgtccgggattacag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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