Basic Information
VIS ID
TVIS44021325
Fusion event
HTLV-1-ZNF112 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
44860049/44355897 (Hg38)
End
44860049/44355897 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF112
Nearest miRNA
hsa-mir-10395/Upstream/2004692; hsa-let-7e/Downstream/297789;
Nearest TSS
ENST00000633603/Upstream/50851; ENST00000592507/Downstream/777;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/50821, chr19-CpG: 21/Downstream/608
Upstream sequence
TGCATTTATTGAACAAATATCAGCGCATCTTCGAGCAGAATTTGCCAGTGAATGATGGAAATATCGTCTTCCCTGAAAAGAAAGGATGATAAGTACTACT
Downstream sequence
CAGGTGAGACTCCGCTGCCAAGTGCCAAAGGGTCATTCCCTCCTTCTCCCTGCAGCCTTTTTCAAGAAGTCAAGGCTAAAGAAGGAAAGGAGGATGGGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate