Basic Information
VIS ID
TVIS44021348
Fusion event
HTLV-1-TASP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
13318528/13337881 (Hg38)
End
13318528/13337881 (Hg38)
Orient
+
Location type
Intronic
Target gene
TASP1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4503 ; hsa-mir-100-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2688186; hsa-mir-1-1/Downstream/5132734;
Nearest TSS
ENST00000382410/Upstream/92512; ENST00000469177/Downstream/30822;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/38581, chr20-CpG: 43/Downstream/300757
Nearby gene
ISM1(+37231) ;
Upstream sequence
AAATGTGAGTGCTTCAGTTAAGCTTTGAGTGTGGCTCTGACAGCTCTTCAGCACCTCTGTCGTGTTATAAATAGGAATTTGGTGGAAATTTAGTACACAT
Downstream sequence
GGAACTTACAAAAGGGGGTTGAGCAAGGCTGATGATGGCTTCTACTGCATTTAAGAAAGCATTTGTCCTTACgttaccagaaaagggtcctgatcgagac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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