Basic Information
VIS ID
TVIS44021380
Fusion event
HTLV-1-ACSS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
33507594/34919791 (Hg38)
End
33507594/34919791 (Hg38)
Orient
-
Location type
Intronic
Target gene
ACSS2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/453373; hsa-mir-1-1/Downstream/70585;
Nearest TSS
ENST00000382410/Upstream/5888; ENST00000490464/Downstream/741;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/42949, chr20-CpG: 63/Downstream/35488
Upstream sequence
TTTTGGAAATGTAGCATTGTCTTTTCTAAATCAAATTAAGACATAAATCCTCAATCTATAGGTGGTGAGGCCCAGGGTGAGACAGTTCAGGTGGAGGGTT
Downstream sequence
TTCATACAGCTGACATGGATGTTCTTTCCCTATGCACCCATGGTTTGGTTGAAGGAGAGCTATTCTGTTAACTCAAGGCCAAGGGTGGGCACAGAGATCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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