Basic Information
VIS ID
TVIS44021395
Fusion event
HTLV-1-PREX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
47325417/48708879 (Hg38)
End
47325417/48708879 (Hg38)
Orient
-
Location type
Intronic
Target gene
PREX1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1541821; hsa-mir-1-1/Downstream/1154980;
Nearest TSS
ENST00000382410/Upstream/16195; ENST00000493140/Downstream/119004;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/43774, chr20-CpG: 206/Downstream/118318
Upstream sequence
agggtctgaggcgggcacatgtctggtatgtaatgaggaacagaaaggaggcagtgtgtctggggtggaataaacgagagagagaaaaacagagagatcc
Downstream sequence
gcggtcacagaggCGGCCCCAACACTGCTcctccccaggcccggttttcttatcataagatgggcataaaaaataccccaccttcacaaggatatgggac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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