Basic Information
VIS ID
TVIS44021402
Fusion event
HTLV-1-CASS4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
54993797/56418741 (Hg38)
End
54993797/56418741 (Hg38)
Orient
+
Location type
Intronic
Target gene
CASS4
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-1273e ; hsa-mir-4727-5p ; hsa-mir-6867-5p ; hsa-mir-636 ; hsa-mir-3650 ; hsa-mir-4522 ; hsa-mir-4769-3p ; hsa-mir-6817-5p ; hsa-mir-4289 ; hsa-mir-6818-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-542-3p ; hsa-mir-4504 ; hsa-mir-6811-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1292-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2350256; hsa-mir-1-1/Downstream/902761;
Nearest TSS
ENST00000382410/Upstream/6433; ENST00000484084/Downstream/49844;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/15026, chr20-CpG: 34/Downstream/49578
Upstream sequence
GTGTACTCTGTCTTTAAAAAAGTAGAACTTTTGATGTTTGAGACCGCTGGTCGCCGTGTCGGGTGGGGAGTGGTTGTGAGCAGAAAAAATAGTAAATCAA
Downstream sequence
GGAGTAGATAGCTTCTATTTATGTGTGTTACGTTTGATTCAGGAACACAATGTACCTttcattccgtcaacaaatattgaatgcctgctgcacaccaggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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