Basic Information
VIS ID
TVIS44021411
Fusion event
HTLV-1-CDH4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
60119619/61544563 (Hg38)
End
60119619/61544563 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDH4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-7111-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6832-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-570-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/979938; hsa-mir-1-1/Downstream/408983;
Nearest TSS
ENST00000382410/Upstream/107016; ENST00000611855/Downstream/25572;
Nearest CpG islands
chr20-CpG: 15/Target, None/Upstream, None/Downstream
Nearest cancer related gene
CDH4(TSG, No orient, 0)
Upstream sequence
CGCAGGGCATCGGGGTCTTCGAAGGAAAGCCCGTGGATTATGCATCCAGGAATTAAAGCAGTCCATGCAATGGCAGCCGCCAAGCAGAGACGGTGACGGG
Downstream sequence
ATCCCTGCGTTGACGGTGGCATGACCGTGTGTGATGGGATGTGCCGGGGGCAGACAGGGCCCACCAGACCCCACGCTGCTCTACTCCGCACCGGCCCCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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