Basic Information
VIS ID
TVIS44021417
Fusion event
HTLV-1-ARFGAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
61917192/63285840 (Hg38)
End
61917192/63285840 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARFGAP1
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-423-3p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-1-1/Upstream/46998; hsa-mir-1914/Downstream/968;
Nearest TSS
ENST00000382410/Upstream/50; ENST00000549076/Downstream/1816;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/902, chr20-CpG: 21/Downstream/307
Upstream sequence
CAGTCGAAGCCAGTCTCCATATTCCACGGCCCTGGGCGTGAGAGCAGGGTGTGCCCCGTGCAGCCCTCAGCCCAGCTTGGCAGTGGCCGCTGTCCTCTGA
Downstream sequence
GACGGGAGGAGAGCTGCCCAGCCTGACAGCCCGAGGGATATGGAAACAACTTGGCCCACTGCGGCCCGGTCAGCCACTAACTGTCACTTCTCCCTCTGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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