Basic Information
VIS ID
TVIS44021429
Fusion event
HTLV-1-SAMSN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
15867795/14495474 (Hg38)
End
15867795/14495474 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
SAMSN1
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-124-3p ; hsa-mir-7-5p
Nearest miRNA
hsa-mir-10396a/Upstream/771200; hsa-let-7c/Downstream/2043615;
Nearest TSS
ENST00000624081/Upstream/111990; ENST00000449214/Downstream/5132;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/111709, chr21-CpG: 171/Downstream/568701
Upstream sequence
TTCTTGAGCAAAGCAGTTTCATAAAAGATAAATAGCTTTCAGTCAGAATAGCCTAACCTGCAATATGCATCTTTTTGACATGTATATTCTAATACTACTC
Downstream sequence
TAGACCATAAGATTAAAATAAGAAAAATCTCAGAGTAGTGTGTTGACAAGAAGCACTGGTTGAATCTGTATTTTTTTTTTCCATTTTTCATCTCCCAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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