Basic Information
VIS ID
TVIS44021431
Fusion event
HTLV-1-chr21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17347601/15975281 (Hg38)
End
17347601/15975281 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA21A
Nearest miRNA
hsa-mir-10396a/Upstream/2251007; hsa-let-7c/Downstream/563808;
Nearest TSS
ENST00000624081/Upstream/46985; ENST00000602935/Downstream/95241;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/244797, chr21-CpG: 138/Downstream/1537207
Nearby gene
USP25(+95211) ;
Upstream sequence
GTATGTTTCCCTTACTACTATGCAAACTTCAAGAAGGGAAACGTTTTCTACAGTATCTAGAATAGTTTTTTGCATAGAGTAGACATACATGAAACAATGA
Downstream sequence
TACACATTAATTACTTTCTCAGTAAGCTTGATAAAATGGAAGATGCTCAATAACAGTTCAGTTTCTTGTCCCTTGAGAAGTGGTGCATGAATTGTAGCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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