Basic Information
VIS ID
TVIS44021435
Fusion event
HTLV-1-CHODL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
19446615/18074297 (Hg38)
End
19446615/18074297 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHODL
Nearest miRNA
hsa-let-7c/Upstream/1483972; hsa-mir-155/Downstream/611793;
Nearest TSS
ENST00000624081/Upstream/156957; ENST00000543733/Downstream/40607;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/254557, chr21-CpG: 77/Downstream/170484
Upstream sequence
CCTGTCAGCCTTTATGAAATTATCCCTGGAAAGAACAGGCTATGTGCATGTCTGTTAGAACAATGAGAATTGCTAAATAACTTCTGACTTAGACACAAGT
Downstream sequence
CACTTGTCACATGAGCAAAATTTAATAACAGACTTTAAGCAATAGTCTTGGATATGGGGCACTCTAAGAATTTCTAAATTAGACTGTTATTACTTGCTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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